then tested for organoleptic, homogeneity test, pH dispersion and physical stability of the preparation. Furthermore, the inhibitory power of 2.5% has a medium category, the inhibition of 5% has a medium category, and the inhibition of 10% has a strong category. Aloe vera ethanol extract was made by maceration method, then the extract was made in a gel preparation and then tested for antibacterial activity against Propionibacterium acnes by the agar diffusion method using several concentration variations: 2.5%, 5%, and 10%. The purpose of this study was to determine the gel preparation of aloe vera extract (Aloe vera (L.) Burm.f.) which has activity against Propionibacterium acnes and to see if the gel preparation produced has good and stable quality.

Department of Pharmacy, Universitas Muslim Nusantara Al Washliyah., Jalan Garu II Medan Amplas 20147, North Sumatra, IndonesiaĪloe vera (Aloe vera (L.) Burm.f.) is widely used as an alternative medicine to treat various types of diseases and is now widely used as an antibacterial, one of which is against the acne bacteria Propionibacterium acnes.

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